There are more than 80 Senior Secondary schools in the region. Some are;
They grouped into district basis:
Adansi North District / Adansi South District
- Akrofuom Secondary/Technical, Akrofuom
- Asare Bediako Secondary, Akrokerri
- Bogwesango Secondary, Bodwesango
- Dompoase Secondary, Dompoase
- New Edubiase Secondary, New Edubiase
- T.I. Ahmadiyya Senior High School, Fomena
Obuasi Municipal District
- Christ the King Catholic Senior High School
- Father Augustine Murphy Commercial School
- Obuasi Secondary/Technical School
- St. Margaret Senior High School (Private)
- Just Love Senior High School (Private)
- Adansi Technical Institute (Private)
Afigya-Sekyere District
- Adu Gyamfi Secondary, Jamasi
- Agona Secondary/Technical, Agona
- Konadu Yiadom Secondary, Asaman
- Okomfo Anokye Secondary, Wiamoase
- S.D.A. Secondary, Agona
- Tetrem Secondary, Tetrem
Ahafo Ano North District
- Maabang Secondary/Technical, Maabang
- Tepa Secondary, Tepa
Ahafo Ano South District
- Mankranso Secondary, Mankranso
Amansie East District
- Jacobu Secondary/Technical, Jacobu
- Oppong Memorial Secondary, Kokofu
- Saint Joseph Secondary/Technical, Ahwiren
- SDA Secondary, Bekwai
- Wesley High School, Bekwai
Amansie West District
- Esase Bontefufuo Secondary, Esase Bontefufuo
- Manso-Adubia Secondary, Adubia
- Mansoman Secondary, Manso Atwere
Asante Akim North District
- Agogo State College, Agogo
- Collins Secondary/Technical, Agogo
- Konongo Odumase Secondary, Odumase
- Owerriman Secondary, Domeabra
Asante Akim South District
- Bompata Presby Secondary, Bompata
- Juaso Secondary/Technical, Juaso
- Ofoase Secondary/Technical, Ofoase
Atwima Mponua District / Atwima Nwabiagya District
- Mpasatia Secondary/Technical, Mpasatia
- Nyinahin Catholic Secondary, Nyinahin
- Osei Tutu Secondary, Akropong
- Toase Secondary, Toase
- Yaa Asantewaa Girls Secondary, Tanoso
Botsomtwe/Atwima/Kwanhuma District
- Afia Kobi Ampem Girls Secondary, Trabuom
- Beposo Secondary, Beposo
- Jachie Pramso Senior High School
- St.Margaret High School,Feyiase
- Ejuraman Secondary, Ejura
- Sekyedumase Secondary, Sekyedumase
Kumasi Metropolitan District
- Adventist Secondary School, Bantama-Kumasi
- Anglican Secondary School, Asem-Kumasi
- Pentecost Secondary School,Breman-kumasi
- Roman Girls Nursing Training School,[Suame-Kumasi]
- Asanteman Secondary School, Bantama
- Ashanti Kingdom Senior High School,Ahodwo Daban-Kumasi
- Kumasi Academy, Asokore Mampong
- Kumasi Girls Secondary School, Abrepo- Kumasi
- Kumasi High School, Atonsu Gyenase
- Kumasi secondary Technical School, Patasi-Kumasi
- Mmofraturo Girls Secondary School, Kumasi
- Opoku Ware School, Kumasi
- Osei Kyeretwie Secondary School, Old Tafo
- Prempeh College, Kumasi
- Engel Educational Complex – Kronom
Kwabre District
- Adanwomase Secondary, Adanwomase
- Aduman Secondary, Aduman
- Antoa Secondary, Antoa
- Gyeama Penson Secondary/Technical, Aboaso
- Kofi Adjei Secondary/Technical, Bampanase
- Simms Secondary, Fawoade
Offinso District
- Akumadan Secondary, Akumadan
- Namong Secondary, Namong
- St. Jerome Secondary, Abofour
Sekyere East District
- Asokore T.I. Ahmad Secondary, Asokore
- Dadease Agriculture Secondary, Dadease
- Effiduase Secondary/Commercial, Effiduase
- Krobea Asante Vocational/Technical Institute, Asokore
- Tweneboa Kodua Secondary School, Kumawu
Sekyere West District
- Amaniampong Secondary, Mampong
- Nsutaman Catholic Secondary, Nsuta
- Saint Joseph Secondary/Commercial School, Mampong
- Saint Monica’s Secondary, Mampong
Ejisu/Juaben District
- Juaben Secondary School, Juaben
- Ejisuman Secondary School, Ejisu
- Ejisu Secondary Technical School, Ejisu
- Bonwire Secondary Technical School, Bonwire
- Achinakrom Secondary School, Ejisu – Achinakrom
- Church of Christ Senior High School – Adade-ntam